By: Ninik Rustanti, Agnes Murdiati, Mohammad Juffrie, Endang Sutriswati Rahayu
ABSTRACT
Association of food intake with intestinal microbiota, short chain fatty acid and metabolic markers in Indonesian women with type 2 diabetes (T2D) has been investigated. The case control study that used subjects of healthy women and women with T2D. The intake were taken with a semi-quantitative food frequency questionnaire (SQ-FFQ) and physical activity data with IPAQ for a month. Then after 1 month, anthropometric data and metabolic markers were taken. Feces were taken for analysis of pH, gut microbiota and SCFA. HbA1c, fasting blood glucose (FBG) and age were different in healthy and T2D women. Macronutrient intake (calories, carbohydrate, protein, fat) and fiber were not different but T2D women had more water intake significantly than healthy women. T2D had more sugar intake but less meat &poultry product intake and fish & seafood product intake than healthy women. Total short chain fatty acid (SCFA), acetic acid, propionic acid, butyric acid, valeric acid and gut microbiota (L. plantarum, Bifidobacterium and Prevotella) were not different significantly in healthy and T2D women. There was correlation between FBG with age, HbA1c, waist hip ratio (WHR) and protein intake. HbA1c correlated with age, waist circumference, WHR. Stool pH correlated with waist circumference, WHR, acetic acid, propionic acid, total SCFA and Prevotella. Acetic, propionic and butyric acid correlated with Prevotella and just propionic acid correlated with carbohydrate intake. Microbiota markers of T2D is Bacteriodetes and Microbiota markers of healthy is Ruminococcaceae.
Keywords: gut microbiota, SCFA, T2D women.
*This poster was presented in The 6th International Conference of Indonesian Society for Lactic Acid Bacteria and Gut Microbiota (6th ISLAB) on 13th August 2021
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